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. 2021 Sep 23;47(2):409–421. doi: 10.1007/s11064-021-03454-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — HIF1A expression was analysed in a cohort of 75 High-Risk (A) and 10 Low-Risk Neuroblastoma patients. Age of diagnosis (from 18 months) did not correlate with HIF1A expression (B). HIF1A mean expression remained unaltered among deceased and alive patients (C) and low-risk and high-risk patients. We evaluated the normalised gene expression of differentiation markers NEFL (E), SYP (F), MAPT (G) and ENO2 (H) and correlated to HIF1A normalised gene expression. There was no correlation between differentiation-related gene expression and HIF1A expression