Table 3.

Docking Score of Interaction of β-Caryophyllene with Agonist Binding Sites of Different Pain Receptors

Receptor	Binding Energy kJ/mol	Ligand Efficiency	Inhibitory Constant (µM)	Vdw_hb_Desolv_Energy	Interactions
Cannabinoid receptor 2 (CB2)	−7.83	−0.52	1.81	−7.84	Ile186, Ile110, Trp194, Phe281, Val113, Phe183, Thr114
Cannabinoid receptor 1 (CB1)	−5.16	−0.34	165.22	−5.16	Phe191, Gly194, Gly195, Ala198, Ile245, Val249
PPAR-α	−6.66	−0.44	13.05	−6.67	Ile241, Leu247, Glu251, Leu254, Arg271, Ile272, Cys275, Val332, Ala333
TRPV1	−7.58	−0.51	2.8	−7.57	Phe488, Arg491, Gly492, Glu513, Phe516, Tyr554