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Snapshots of the RNase H1 active site upon catalysis. (A) In the product state, KW is stably coordinated at the active site, while KV is only transiently observed. (B) KW and KV can exchange their position with K196, which directly coordinates the scissile phosphate preventing its misfolding. (C) The third additional MC binds the scissile phosphate and promotes the increase of the distance between the two catalytic MA–MB ions for product release.
