Table 3. Mortality associated with perioperative hypertension.
| Author | Year | Sample size | Definition of hypertension | Result* | P-value | Duration |
|---|---|---|---|---|---|---|
| Aronson et al.# [15] | 2010 | 7,504 | AUC >135 (mmHg x min) | 1.02 (0.991–1.055) | 0.16 | 30-day |
| Excursions >135 [AUC for 20% (mmHg x min)] | 0.99 (0.929–1.058) | 0.79 | 30-day | |||
| Min >135 mmHg per excursion | 1.03 (1.001–1.055) | 0.04 | 30-day | |||
| Mean excursion peak >135 mmHg | 1.01 (0.989–1.016) | 0.14 | 30-day | |||
| Balzer et al.# [18] | 2016 | 5,225 | >130 mmHg postoperative | 0.001 | 30-day | |
| Jinadasa et al.# [31] | 2018 | 3,687 | SBP coefficient of variation | 2.50 (1.60–3.92) | <0.01 | 30-day |
| Pre bypass coefficient of variation | 1.75 (1.17–2.62) | 0.01 | 30-day | |||
| Post bypass coefficient of variation | 1.40 (0.97–2.04) | 0.08 | 30-day | |||
| MAP coefficient of variation | 1.16 (0.98–1.37) | 0.09 | 30-day | |||
| Pre bypass coefficient of variation | 1.08 (0.95–1.23) | 0.24 | 30-day | |||
| Bypass coefficient of variation | 1.07 (0.87–1.31) | 0.53 | 30-day | |||
| Post bypass coefficient of variation | 1.06 (0.85–1.32) | 0.63 | 30-day | |||
| McIlroy et al.# [45] | 2019 | 793 | SBP 1 mmHg increase | 0.98 (0.94–1.02) | 0.35 | Hospital mortality |
| MAP 1 mmHg increase | 0.91 (0.84–0.99) | 0.03 | Hospital mortality | |||
| Abbott et al. [12] | 2018 | 16,079 | SBP >160 mmHg | 0.76 (0.58–0.99) | 0.04 | 30-day |
| Levin et al. [35] | 2015 | 52,919 | Baseline MAP (per 10 mmHg increase); Derivation cohort | 0.89 (0.84–0.95) | <0.001 | 30-day |
| Baseline MAP (per 10 mmHg increase); Validation cohort | 0.91 (0.84–0.99) | 0.03 | 30-day | |||
| MAP >120 mmHg, per 5 min increase; Derivation cohort | 0.91 (0.84–0.99) | 0.03 | 30-day | |||
| MAP >120 mmHg, per 5 min increase; Validation cohort | 1.00 (0.93–1.08) | 0.98 | 30-day | |||
| McCarthy et al. [44] | 2020 | 212 | Maximum SBP day 1 (increases of 10 mmHg) | - | ||
| Maximum SBP day 2 (increases of 10 mmHg) | 1.28 (1.04–1.58) | 0.021 | Last follow-up (median 89.5 days) | |||
| Maximum SBP day 3 (increases of 10 mmHg) | 1.30 (1.06–1.63) | 0.015 | Last follow-up (median 89.5 days) | |||
| Peak SBP change from day 1 to 2 | - | |||||
| Peak SBP change from day 2 to 3 | - | |||||
| Monk et al. [47] | 2015 | 18,756 | SBP >180 mmHg for >5 min (Reference 90–159 mmHg) | 0.904 (0.545–1.500) | 1 | 30-day |
| MAP >130mmHg for >5 min | 0.947 (0.624–1.435) | 1 | 30-day | |||
| DBP >120 mmHg for >5 min | 1.357 (0.714–2.580) | 1 | 30-day | |||
| Yu et al. [74] | 2016 | 358 | Preoperative SBP ≥120 mmHg | 1.97 (1.08–3.60) HR | 0.028 | Disease-free survival |
| Preoperative SBP ≥120 mmHg | 2.85 (1.00–8.25) HR | 0.05 | Cancer-free survival | |||
| Zheng et al. [76] | 2020 | 173 | 24h post-CAS BP <120 mmHg | 0% Incidence | 0.001 | In-hospital death |
| 24h post-CAS BP 120–130 mmHg | 0% Incidence | In-hospital death | ||||
| 24h post-CAS BP >130 mmHg | 16.70% Incidence | In-hospital death |
Abbreviations: AUC: area under the curve, CAS: carotid angioplasty stenting, CI: confidence interval, DBP: diastolic blood pressure, HR: hazard ratio, MAP: mean arterial pressure, min: minutes, OR: odds ratio, SBP: systolic blood pressure.
*Generally, OR (95% CI), unless otherwise stated.
#These articles refer to cardiac surgery.