Table 4. Mortality associated with perioperative variability in blood pressure (and other measures of blood pressure).

Author	Year	Sample size	Definition of measure	Result*	P-value	Duration	Measure
Aronson et al.# [16]	2011	1,512	SBP, 65–135 mmHg intraoperative 75–145 mmHg pre and post	1.142 (0.989–1.319)	0.0707	30-day	SBP Variability
			SBP, 75–135 mmHg intraoperative 85–145 mmHg pre and post	1.16 (1.039–1.295)	0.0082	30-day	SBP Variability
			SBP, 85–135 mmHg intraoperative 95–145 mmHg pre and post	1.18 (1.076–1.295)	0.0005	30-day	SBP Variability
			SBP, 95–135 mmHg intraoperative 105–145 mmHg pre and post	1.153 (1.074–1.238)	<0.01	30-day	SBP Variability
			SBP, 105–135 mmHg intraoperative 115–145 mmHg pre and post	1.105 (1.053–1.160)	<0.01	30-day	SBP Variability
Ono et al.# [51]	2014	450	AUC MAP<LLA (mmHg x min/h)	1.36 (1.08–1.71)	0.008	Morbidity or mortality	MAP below limit of autoregulation
Mascha et al. [42]	2015	104,401	Average real variability-MAP 25th percentile	1.14 (1.03–1.25)	0.01	30-day	MAP Variability
			Average real variability-MAP median	1.0 (reference)		30-day	MAP Variability
			Average real variability-MAP 75th percentile	0.94 (0.88–0.99)	0.018	30-day	MAP Variability
			10-min sustained minimum MAP (mmHg) minimum MAP <70	0.76 (0.72–0.80)	<0.01	30-day	MAP Variability
			10-min sustained minimum MAP (mmHg) minimum MAP ≥70	1.02 (0.95–1.10)	0.59	30-day	MAP Variability
			Cumulative min of MAP <50 mmHg (10 min)	1.23 (1.15–1.30)	<0.001	30-day	MAP Variability
			Cumulative min of MAP <55 mmHg (10 min)	1.13 (1.09–1.17)	<0.001	30-day	MAP Variability
			Cumulative min of MAP <60 mmHg (10 min)	1.09 (1.07–1.11)	<0.001	30-day	MAP Variability
			Cumulative min of MAP <70 mmHg (10 min)	1.04 (1.03–1.05)	<0.001	30-day	MAP Variability
			Cumulative min of MAP <80 mmHg (10 min)	1.02 (1.01–1.03)	<0.001	30-day	MAP Variability
Wiorek and Krzych. [71]	2019	835	SBP variability per 1%	1.10 (1.00–1.21)	0.05	30-day	SBP Variability
			Mean BP variability per 1%	1.10 (0.99–1.23)	0.06	30-day	SBP Variability
			DBP variability per 1%	1.10 (1.01–1.21)	0.03	30-day	SBP Variability
Wu et al. [72]	2017	678	MAP 65 to 79 mmHg	3% Incidence	0.671	28-day mortality incidence	Control of MAP
			MAP 80 to 95 mmHg	2.9% Incidence			Control of MAP
			MAP 96 to 110 mmHg	3.8% Incidence			Control of MAP

Abbreviations: AUC _MAP<LLA: area under the curve of mean arterial pressure less than the lower limit of autoregulation during the cardiopulmonary bypass, BP: blood pressure, CI: confidence interval, DBP: diastolic blood pressure, MAP: mean arterial pressure, min: minutes, OR: odds ratio, SBP: systolic blood pressure.

*Generally, OR (95% CI), unless otherwise stated.

^# These articles refer to cardiac surgery.