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. 2022 Feb 9;8(6):eabh4315. doi: 10.1126/sciadv.abh4315

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Fig. 3. — (A) Top: Example of an individual experiment showing EPSCs from an SPN when photostimulating ChAT-ChR2-EYFP neurons before (ACSF, magenta) and after DNQX and APV (gray). Bottom: EPSC charge and peak amplitude as a function of time, for the same experiment of the traces above. Shadowed areas highlight the individual trials averaged for each condition (magenta, ACSF; light gray, DNQX and APV). (B and C) EPSC charge (B) and amplitude (C) for individual SPNs in ACSF (magenta) and DNQX and APV (gray) conditions. n = 8 SPNs from four ChAT-ChR2-EYFP mice. Bars represent means. P = 0.0078125 (B); P = 0.0078125 (C); Wilcoxon signed-rank test. (D) Top: Example of an individual experiment showing EPSCs from an SPN when photostimulating ChAT-ChR2-EYFP neurons before (ACSF, magenta) and after MLA (black). Bottom: EPSC charge and peak amplitude as a function of time, for the same experiment of the traces above. Shadowed areas highlight the individual trials (thin light-gray traces above) averaged for each condition (magenta, ACSF; dark gray, MLA). (E and F) EPSC charge (E) and amplitude (F) for individual SPNs in ACSF (magenta) and MLA (black) conditions. n = 10 SPNs from five ChAT-ChR2-EYFP mice. Bars represent means. P = 0.0019531 (E); P = 0.0039063 (F); Wilcoxon signed-rank test.