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. 2022 Feb 9;8(6):eabh4315. doi: 10.1126/sciadv.abh4315

Fig. 6. PT neurons amplify excitatory inputs to striatum through ChIs.

Fig. 6.

Summary of the results: left, circuit diagram proposed for corticostriatal connectivity. IT and PT cortical neurons project to both SPNs (1) and ChIs (2). While PT➔SPN (1, red) and PT➔ChI (2, red) input strength is similar, IT➔ChI (2, blue) connection is weaker than IT➔SPN (1, blue). Within the striatum, ChIs convey excitation to SPNs by recruiting long-range glutamate-releasing terminals reaching DLS through α4-containing nicotinic receptors (3 and inset). Inset shows the putative axonal sources of glutamate release during the second EPSC peak. Ach, acetylcholine; α4-nAchR, α4-containing nicotinic receptors; Glut, glutamate. Right: Schematic of the activation of the different circuit players upon IT or PT photostimulation and its impact on the recorded SPNs. Magenta horizontal lines represent ChI spiking threshold.