Table 1. Equilibrium binding constants.

Nucleic acid substrate	kd in nM (range of Kd in nM)
	Full-length METTL3-METTL14	METTL3-METTL14-RGG
RNA
rNEAT2	2.1 (1.8–2.3)	21.2 (19.2–23.5)
rNEAT2*	13.0 (12.3–13.8)	274.1 (150.7–497.2)
rTCE23	25.6 (23.2–28.5)	413 (341–502)
rPal-top+ bot	127 (97.2–167)	257 (132–491)
rFoxM1-p1	294 (245–354)	920 (480–1940)
r6T	114 (103–127)	704 (323–1668)
DNA
d6T	370 (343–401)	2097 (1494 – >2000)
d6T*	509 (470–553)	>2000