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. 2022 Feb 2;2022:7931393. doi: 10.1155/2022/7931393

Figure 7.

Figure 7

Discrepancy between the low-risk group and the high-risk group in terms of immunologic functions, immune checkpoint analysis, and N6-methyladenosine-related gene analysis. (a) The box plot of immunologic function analysis. APC: antigen-presenting cell; CCR: chemokine receptors; HLA: human leukocyte antigen; MHC class I: major histocompatibility complex class I; Type I IFN response: type I interferon response. (b) The box plot of immune checkpoint analysis. LGALS9: galectin 9; HAVCR2: hepatitis A virus cellular receptor 2; TNFRSF8: TNF receptor superfamily member 8; NRP1: neuropilin 1; TNFSF4: TNF superfamily member 4; CD48: CD48 molecule; CD27: CD27 molecule; IDO1: indoleamine 2,3-dioxygenase 1; PDCD1LG2: programmed cell death 1 ligand 2; TNFRSF25: TNF receptor superfamily member 25; CD274: CD274 molecule; CD44: CD44 molecule; CTLA4: cytotoxic T lymphocyte-associated protein 4; IDO2: indoleamine 2,3-dioxygenase 2; BTLA: B and T lymphocyte-associated; LAIR1: leukocyte-associated immunoglobulin like receptor 1; CD86: CD86 molecule; CD80: CD80 molecule; TIGIT: T cell immunoreceptor with Ig and ITIM domains; TNFSF18: TNF superfamily member 18; CD200: CD200 molecule; CD40LG: CD40 ligand; TNFRSF4: TNF receptor superfamily member 4; PDCD1: programmed cell death 1; LAG3: lymphocyte-activating 3; TNFRSF9: TNF receptor superfamily member 9; CD28: CD28 molecule; TNFSF14: TNF superfamily member 14; ICOS: inducible T cell costimulator. (c) Box plot of N6-methyladenosine-related gene analysis. YTHDC1: YTH domain-containing 1; RBM15: RNA-binding motif protein 15 ZC3H13: zinc finger CCCH-type containing 13; FTO: FTO alpha-ketoglutarate-dependent dioxygenase; ALKBH5: AlkB homolog 5, RNA demethylase; WTAP: WT1-associated protein; HNRNPC: heterogeneous nuclear ribonucleoprotein C; YTHDC2: YTH domain-containing 2; YTHDF2: YTH N6-methyladenosine RNA-binding protein 2; METTL3: methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit; METTL14: methyltransferase 14, N6-adenosine-methyltransferase subunit YTHDF1: YTH N6-methyladenosine RNA-binding protein 1.