Fig. 1.

(A) Time course of serum cytokines. The values of day 5 was measured before treatment. Note that the elevated cytokine levels were normalized rapidly after treatment, along with the convalescence from the illness. (B) Time course of T-cell subsets. Some T-cell subsets had characteristic kinetics. The dashed lines indicate the median value of healthy children around the same age as the patient according to reference [[28], [29], [30], [31]]. The total T-cell kinetics were included in each graph as comparison. (C) Time course of T-cell receptor repertories. The expansion of Vβ 21.3 in both memory CD4+ and CD8+ T cells was seen on day 12. A similar trend was seen in HLA-DR+ CD4+ and CD8+ T cells. The peripheral blood from a healthy 11-year-old boy was used as control.