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Effect of ΔmtDNA accumulation on proteinuria. Mito-miceΔ with more than 80% ΔmtDNA in the kidneys developed proteinuria. This is consistent with the previous observations that threshold of mitochondrial respiratory defect in mito-miceΔ was around 85% ΔmtDNA accumulation. B6 control (n=3), mito-miceΔ (n=18).
