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. 2021 Jul 28;71(1):14–21. doi: 10.1538/expanim.21-0054

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©2022 Japanese Association for Laboratory Animal Science

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)

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Fig. 2. — Light microscopy of glomerular and tubulointerstitial involvements. (a) Sample No. 18 (25 week-old, ΔmtDNA 93.0%). A glomerulus revealed segmental sclerosis on the left side. Some tubular casts were seen. (b), (c) Sample No. 18 (25 week-old, ΔmtDNA 93.0%). Tubular dilatation with hyaline casts was frequently seen in both renal cortex (b) and medulla (c). The appearance of these tubular casts was originated from glomerular proteinuria. (a): PAS stain, (b), (c): MT stain.