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. 2021 Jul 28;71(1):14–21. doi: 10.1538/expanim.21-0054

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©2022 Japanese Association for Laboratory Animal Science

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)

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Fig. 6. — The relationship between accumulation of ΔmtDNA in the kidney and podocyte number. (a) Overall scatter plot. In control mice (n=3), the median number of WT1 positive cells per glomerulus was 6.2 cells. The number of WT1 positive cells was decreasing in mito-miceΔ with the proportion of ΔmtDNA exceeding a median of 81.7%. (b) Comparing medians of two groups, high proportion of ΔmtDNA group and low proportion group. The WT1-positive podocyte number was statistically significant decreasing in the group with higher proportion of ΔmtDNA in kidney (median 6.1 cells vs median 4.5 cells, P=0.029). B6 control (n=3), mito-miceΔ (n=8).