Table 1. Biochemical and histological characteristics of mice.

Sample number		Age at sacrifice (weeks)	Proportion of ΔmtDNA 4-week tail (%)	Proportion of ΔmtDNA Kidney at sacrifice (%)	Urinary protein (g/gCr)	Number of total glomeruli	Number of global sclerosis (%)	Number of segmental lesion (%)	Tubular dilatation	Interstitial fibrosis (%)
Control
	B6(12)	12		0	3.9	147	0	0	no	<5
	B6(18)	18		0	2.9	211	0	0	no	<5
	B6(22)	22		0	3.1	181	0	0	no	<5
Mito-miceΔ
	1	16	14.6	40.5	4.6	170	0	0	no	<5
	2	16	27.2	45.2	4.9	168	0	0	no	<5
	3	12	67.6	71.9	8.1	88	0	0	no	<5
	4	12	68.5	75.0	5.3	78	0	0	no	<5
	5	22	37.9	76.0	9.8	93	0	0	no	<5
	6	18	60.0	79.3	9.5	76	0	0	no	<5
	7	12	60.0	79.4	4.1	215	0	0	no	<5
	8	22	29.6	79.4	12.2	70	0	0	no	<5
	9	12	62.9	79.6	4.1	66	0	0	no	<5
	10	13	73.0	80.1	3.6	163	0	0	no	<5
	11	16	69.6	83.7	28.1	183	0	0	no	<5
	12	22	60.0	83.9	2.5	147	0	0	no	<5
	13	17	60.0	84.0	31.1	157	0	0	no	<5
	14	16	66.5	86.1	9.0	237	0	0	no	<5
	15	24	68.0	90.8	53.3	159	10 (6.3)	7 (4.4)	yes	<5
	16	22	71.2	92.2	85.9	94	22 (23.4)	20 (21.3)	yes	<5
	17	22	63.3	92.9	31.9	102	0 (0)	1 (1.0)	yes	<5
	18	25	67.0	93.0	42.4	177	1 (0.6)	12 (6.8)	yes	<5