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. 2022 Feb 10;3(3):100535. doi: 10.1016/j.xcrm.2022.100535

Figure 3.

Figure 3

BTI results in increased plasma neutralization titers against all SARS-CoV-2 variants, and SARS-CoV-1, 6 months post-vaccination

The neutralization titers against the ancestral (D614G), Beta (B.1.351), Delta (B.1.617.2), Gamma (P.1), C.1.2, A.VOI.V2, and Omicron (B.1.1.529) SARS-CoV-2 variants, and SARS-CoV-1, for six BTI participants relative to 13 non-BTI participants at the 6-month post-vaccination visit (approximately 1 month post-BTI). Each dot represents the neutralization titer of a single participant, with the BTI participants and non-BTI participants shown in red and blue, respectively. The GMT for each group against each variant is shown by a black horizontal bar in the plot, with the values given in the red and blue boxes above the plot. Neutralization titers in the BTI group were significantly higher than those of the non-BTI group (40- to 154-fold higher GMT against the SARS-CoV-2 variants and 9-fold higher against SARS-CoV-1). All results are the mean of two independent experiments. Statistical analyses were performed using the Mann-Whitney test between groups, with ∗∗∗ denoting p < 0.001 and ∗∗∗∗ denoting p < 0.0001.