Figure 2.

The effect of the mutations of RBDs on interactions with bamlanivimab for currently identified SARS-CoV-2 VOC and VOI (with the exception of the Omicron variant). (A) The amino acids which have been mutated in the variants are shown on the ancestral RBD overlaying with ACE2 and bamlanivimab. Key ancestral and variant mutations that affect bamlanivimab affinity are shown in the following: (B) for ancestral glutamic acid 484, (C) for E484K mutation, (D) for ancestral leucine 452, (E) for L452R, (F) for L452Q mutation, (G) for ancestral phenylalanine 490, and (H) for F490S mutation. Bam, bamlanivimab. We used 7KMG (PDB ID) for bamlanivimab and RBD modeling.