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. 2021 Nov 25;602(7896):300–306. doi: 10.1038/s41586-021-04266-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — a, Neutralization assay using three monoclonal antibodies (clones 8A5, 4A3 and CB6). Assays were performed in triplicate. b,c, Neutralization assay using 19 vaccinated sera. Pseudoviruses and effector cells (S-expressing cells) were treated with serially diluted NAbs or sera as described in Methods. Assays were performed in triplicate. The raw data of panel b are shown in panel c. NT₅₀, 50% neutralization titre. In b, each dot indicates the mean NT₅₀ value of the respective donor. A statistically significant difference versus the D614G virus was determined by two-sided Wilcoxon matched-pairs signed rank test. In c, the NT₅₀ values of D614G S (black) and D614G/P681R S (orange) for each serum are indicated in each panel.