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. 2021 Nov 25;602(7896):300–306. doi: 10.1038/s41586-021-04266-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — a, MicroCT axial and coronal images of the lungs of Syrian hamsters at 7 d.p.i. with D614G-infected (n = 4), D614G/P681R-infected (n = 4), and uninfected hamsters (n = 3). Lung abnormalities included multifocal nodules (black arrows), ground glass opacity (white arrowheads), and regions of lung consolidation (white arrows) that were peripheral, bilateral, and multilobar. Pneumomediastinum is labelled with white asterisks. b, Summary of CT severity score. CT severity score of D614G-infected (n = 4), D614G/P681R-infected (n = 4), and uninfected hamsters (n = 3) Syrian hamsters. Each dot indicates the result of the respective infected hamster. Note that D614G/P681R-infected animals had a higher average CT severity score compared to D614G-infected animals.