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. 2021 Nov 25;602(7896):300–306. doi: 10.1038/s41586-021-04266-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a, A plaque assay was performed using VeroE6/TMPRSS2 cells as described in Method. Representative figures (top) and the summary of the size of plaques (n = 20 for each virus) are shown. Each dot indicates the diameter of the respective plaque. b, Chromatograms of nucleotide positions 23,399-23,407 (left) and 23,600-23,608 (right) of parental SARS-CoV-2 (strain WK-521, PANGO lineage A; GISAID ID: EPI_ISL_408667) and the D614G (A23403G in nucleotide) and P681R (C23604G in nucleotide) mutations. c, A plaque assay was performed using VeroE6/TMPRSS2 cells as described in Method. Representative figures (top) and the summary of the size of plaques (n = 20 for each virus) are shown. Each dot indicates the diameter of the respective plaque. Data are mean ± S.D (a, c). Statistically significant differences between B.1.1 and B.1.617.2/Delta (a, *P < 0.05) and between D614G and D614G/P681R (c, *P < 0.05) were determined by two-sided Mann-Whitney U test.