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. 2021 Nov 25;602(7896):300–306. doi: 10.1038/s41586-021-04266-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a, Representative pathological features of lung including bronchitis/bronchiolitis, haemorrhage/congestion, alveolar damage with apoptosis and macrophage infiltration, presence of type II pneumocytes, and presence of the area of large type II pneumocytes are shown. 0 (negative), 1 (weak), 2 (moderate), and 3 (severe). Bars, 50 μm. b, Morphometrical analysis of the area of large type II pneumocytes. The area of the large type II pneumocytes with the nuclear diameter more than 8 μm in the lung specimens at 5 d.p.i. was measured, and the percentage of this area in the whole lung tissue area was calculated. Representative photographs of the lung tissue specimens with B.1.1 isolate (top) and B.1.617.2/Delta isolate (bottom) infections are shown. Red line indicates the area with the presence of large type II pneumocytes. Note that the most left panels (hamsters #89 and 90) are identical to the panels shown in Fig. 2g. c, IHC of the viral N proteins in the lung of infected hamsters. Representative IHC panels of the viral N proteins in the lung of hamsters infected with D614G-bearing B.1.1 isolate (left) and B.1.617.2/Delta isolates (right) are shown. Serial sections were used for H&E staining (top) and IHC (bottom). Bars, 250 μm (1, 3, and 7 d.p.i.) or 500 μm (5 d.p.i.).