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. 2021 Dec 23;602(7896):314–320. doi: 10.1038/s41586-021-04356-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b, VH (a) and VK (b) gene usage by anchor-binding mAbs. The number in the centre of the pie graphs indicates the number of mAbs analysed. c, Cryo-EM structure of anchor-targeting 222-1C06 (blue) and lateral patch-targeting 045-09 2B05 (dark grey; see Methods) binding to A/California/7/2009 (E376K) HA (light grey). d, Heavy chain and light chain footprint of 222-1C06 binding to HA based on the cryo-EM structure. e, HA epitope contact residues (maroon) and heavy chain (green) and light chain (yellow) antibody contact residues of the 222-1C06 paratope. Peach-highlighted amino acids represent the fusion peptide of HA2. f, K-CDR3 NWP and H-CDR2 Y58 motifs of 222-1C06. Bold residues are HA residues. g, Major contacts of 222-1C06 K-CDR1 and H-CDR3 (normal typeface) binding to HA (bold residues). h, i, Weblogo plot and germline sequence of Y58 following the H-CDR2 motif (h) and the K-CDR3 NWP motif (i). j, k, Amino acid conservation of s contact residues across human, swine and avian H1 viruses (j) and group 1 influenza A viruses (k). Bold residues are contacts conserved with A/California/7/2009 H1N1 (k). The strain information used for conservation models in j and k are in Supplementary Tables 4, 5, respectively. See also Extended Data Fig. 4.

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