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. 2022 Jan 13;19(2):159–170. doi: 10.1038/s41592-021-01346-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a. CellRank-computed initial and terminal states from Fig. 2d. b. Cells are colored based on the expression level of the indicated gene in each UMAP. The terminal states express the key marker genes relevant for each respective cell type. Showing for beta: Ins1 and Ins2 (insulin), alpha: Gcg (glucagon), epsilon: Ghrl (ghrelin), delta: Sst (somatostatin)³³. For the initial state, we show expression of ductal cell markers Sox9, Anxa2 and Bicc1^24,33.