Table 5.
Factors influencing pentafecta achievement: univariate (A) and multivariate analysis (B).
| A | OR | 95% CI | p-Value | |
|---|---|---|---|---|
| Age | 0.988 | 0.956–1.020 | 0.4601 | |
| Male gender | 1.081 | 0.574–2.036 | 0.8106 | |
| Ever smoker | 1.044 | 0.521–2.093 | 0.9027 | |
| Hydronephrosis | 0.595 | 0.315–1.121 | 0.1082 | |
| NAC | 0.746 | 0.387–1.437 | 0.3807 | |
| Open surgery | 0.422 | 0.242–0.737 | 0.0024 | |
| BMI | 1.031 | 0.969–1.097 | 0.3299 | |
| Urinary diversion | <0.0001 | |||
| UCS/TU-UCS | Ref | |||
| Ileal conduit | 3.728 | 2.026–6.860 | ||
| Orthotopic neobladder | 23.667 | 4.439–126.194 | ||
| Other diversions | – | 0.001–999 | ||
| MIBC | 0.441 | 0.250–0.780 | 0.0049 | |
| pT3–T4 | 0.286 | 0.153–0.536 | <0.0001 | |
| Pure urothelial histology | 0.427 | 0.211–0.864 | 0.0179 | |
| Transfusion | 0.361 | 0.200–0.650 | 0.0007 | |
| Preop. Hemoglobin | 1.042 | 0.912–1.190 | 0.5459 | |
| Creatinine > 1 mg/dl | 0.344 | 0.195–0.606 | 0.0002 | |
| B | ||||
| Open surgery | 0.349 | 0.172–0.707 | <0.0001 | |
| Urinary diversion | ||||
| UCS/TU-UCS | Ref | <0.0001 | ||
| Ileal conduit | 4.633 | 2.259–9.502 | ||
| Orthotopic neobladder | 20.828 | 3.201–135.524 | ||
| Other UD | <0.001 | <0.001–>999.999 | ||
| Pure urothelial histology | 0.387 | 0.172–0.869 | 0.0192 | |
| pT3–T4 | 0.403 | 0.200–0.812 | 0.0176 | |
| Creatinine > 1 mg/dl | 0.476 | 0.254–0.890 | 0.0062 | |
OR, odds ratio; NAC, neoadjuvant chemotherapy; BMI, body mass index; UCS, uretero-ureterocutaneostomy; TU-UCS, transuretero-ureterocutaneostomy; MIBC, muscle-invasive bladder cancer; UD, urinary diversion.