Figure 2.
Epoch workflow and benchmarking
(A) Epoch relies on a 3-step process to reconstruct dynamic network structures: (1) extraction of dynamic genes and CLR, (2) application of cross-weighting, and (3) extraction of the dynamic network.
(B) BEELINE benchmarking on synthetic data. Epoch using mutual information (MI) and Pearson, denoted by “MI” and “P,” respectively. “X” indicates the use of cross-weighting. The red line indicates the median AUPR of the best-performing method, Epoch using MI + cross-weighting on size 5,000 cell datasets. Kruskal-Wallis p < 2.2 × 10−16. See also Figures S2 and S3.