Figure 4.
Mesodermal network analysis
(A) The epoch 3 subnetwork of the mesodermal dynamic GRN. TFs are colored by community and faded by betweenness. Blue and red edges represent activating and repressive edges, respectively.
(B) Average community expression over time by treatment along the mesodermal path. Communities shown (each row) are from the epoch 2 subnetwork (yellow), transition (green), and epoch 3 subnetwork (aqua).
(C) The epoch 3 differential network between WAG and WA. Interactions in this network represent edges present in the WAG mesodermal network that are not present in the WA mesodermal network. TFs are colored by community and faded by betweenness. Blue and red edges represent activating and repressive edges, respectively.
(D) Peg3 and Dnmt3a expression in a sampled portion of relevant cell types in gastrulation data adapted from Grosswendt et al. (2020). Peg3 ANOVA p < 2 × 10−16, Dnmt3a ANOVA p < 2 × 10−16.