Figure 7.

Comparison to in vivo gastrulation and mesoderm specification

(A) Top regulators of each epoch in the in vivo mesoderm network as predicted by PageRank and Betweenness-Degree.

(B) Shortest path analysis showing length of shortest paths from Wnt effector targets (each row) to mesodermal target genes (each column) in the in vivo network. Path lengths are normalized against average path length in the network. Blue and red indicate paths that activate and repress the target gene, respectively. If such a path does not exist, then it has length of infinity and is white.

(C) Top 10 enriched terms for in vivo- and in vitro-specific modules based on the Combined Score from Enrichr GSEA analysis. See also Figure S7.