Fig 1.

Risk of incident clinical fracture by CML quartile. CML quartile 1 (CML < 576 ng/mL, n = 97 diabetes, n = 553 non-diabetes) was the reference group for comparisons with quartile 2 (CML 576–691 ng/mL, n = 107 diabetes, n = 547 non-diabetes), quartile 3 (CML 691–849 ng/mL, n = 154 diabetes, n = 555 non-diabetes), and quartile 4 (CML ≥849 ng/mL, n = 275 diabetes, n = 558 non-diabetes). Quartile cut points determined from the non-diabetes group. The vertical bars denote 95% confidence intervals. Models include age, race, sex, clinic site, current smoking status, total hip BMD, weight, weight loss of 5+ pounds in year before baseline, cystatin-C, A1c, and medication use (vitamin D supplements, calcium supplements, oral steroids, osteoporosis drugs, thiazide diuretics, statins, oral estrogen and, in models with diabetes participants, use of insulin and thiazolidinediones, and diabetes duration).