Table 2:

Factor Scores Across Treatment Conditions and Assessment Time Points

	Pre Midazolam (SD)	Post Midazolam (SD)	Pre Ketamine (SD)	Post Ketamine (SD)	Significance: Time Effect	Significance: Drug Effect	Significance: Time Effect x Drug Effect
Total Scores
SSI	16.9 (5.8)	13.3 (8.4)	15.55 (6.2)	7.2 (6.4)	<0.001	0.004	0.008
HDRS-24	30.3 (6.0)	24.0 (8.8)	29.4 (6.2)	20.0 (9.7)	<0.001	0.091	0.116
BDI	33.1 (9.2)	25.0 (12.2)	31.7 (8.0)	18.8 (10.7)	<0.001	0.065	0.053
POMS	101.7 (35.2)	85.5 (46.2)	95.9 (37.4)	61.3 (45.5)	<0.001	0.064	0.053
HDRS Factors
HDRS: Psychic Depression	11.1 (2.7)	8.8 (4.0)	11.5 (2.7)	7.3 (3.9)	<0.001	0.0378	0.028
HDRS: Loss of Motivated Behavior	6.1 (1.5)	4.7 (2.1)	5.8 (1.9)	3.8 (2.7)	<0.001	0.100	0.303
HDRS: Disturbed Thinking	0. 8 (1.3)	0.4 (0.7)	0.5 (1.2)	0.4 (0.8)	0.019	0.504	0.427
HDRS: Anxiety	4.3 (2.4)	3.8 (2.0)	4.1 (1.8)	2.7 (1.7)	<0.001	0.119	0.052
HDRS: Sleep Disturbance	3.1 (1.8)	2.3 (1.8)	2.5 (1.8)	2.5 (1.7)	0.122	0.617	0.122
BDI Factors
BDI: Subjective Depression	17.3 (4.9)	13.1 (6.1)	17.5 (4.2)	10.4 (6.8)	<0.001	0.246	0.039
BDI: Self-Blame	8.4 (3.5)	6.5 (4.0)	7.6 (3.2)	4.7 (3.2)	<0.001	0.073	0.220
BDI: Somatic Complaint	2.7 (2.1)	1.7 (1.9)	2.4 (1.8)	1.5 (1.6)	<0.001	0.517	0.825
POMS Subscales
POMS: Depression	39.5 (12.8)	33.9 (17.7)	35.6 (14.6)	23.6 (16.1)	<0.001	0.023	0.046
POMS: Tension	20.2 (9.4)	16.8 (10.5)	19.2 (8.7)	13.6 (9.4)	<0.001	0.273	0.219
POMS: Anger	10.3 (9.9)	9.1 (11.5)	10.1 (9.7)	6.5 (8.6)	0.020	0.482	0.219
POMS: Confusion	15.7 (5.5)	13.9 (6.4)	15.4 (5.3)	11.3 (7.2)	<0.001	0.216	0.122
POMS: Vigor	3.5 (3.4)	27.2 (5.6)	2.9 (2.5)	26.3 (6.0)	0.003	0.836	0.290
POMS: Fatigue	19.4 (6.3)	16.7 (8.2)	18.5 (6.5)	12.1 (7.6)	<0.001	0.048	0.043

SSI = Beck Scale for Suicidal Ideation; MDD = Major Depressive Disorder; HDRS-24 = 24 item Hamilton Depression Rating Scale; BDI = Beck Depression inventory; POMS = Profile of Mood Stat