TABLE 2.
Association of CHDs with diagnosed anxiety, PTSD, and/or depressive disorder, MarketScan® Commercial Database, 2017
| No CHDs | Any CHDsa | Any severe CHDsa | Any nonsevere CHDs | Any CHDs aPRb | Severe CHDs aPRb | Nonsevere CHDsaPRb | |
|---|---|---|---|---|---|---|---|
| Condition | n (%) | n (%) | n (%) | n (%) | (95% CI) | (95% CI) | (95% CI) |
| Total N | 5,408,094 | 13,807 | 3,977 | 9,830 | |||
| Any anxiety or depressive disorderc | 523,022 (9.7) | 1,713 (12.4) | 513 (12.9) | 1,200 (12.2) | 1.3 (1.2–1.4) | 1.3 (1.2–1.5) | 1.3 (1.2–1.3) |
| Anxiety disorder | 403,164 (7.5) | 1,371 (9.9) | 398 (10.0) | 973 (9.9) | 1.3 (1.3–1.4) | 1.3 (1.2–1.5) | 1.3 (1.3–1.4) |
| Post-traumatic stress disorderc | 29,206 (0.5) | 110 (0.8) | 34 (0.9) | 76 (0.8) | 1.5 (1.2–1.8) | 1.6 (1.1–.2.2) | 1.4 (1.2–1.8) |
| Depressive disorder | 267,644 (4.9) | 871 (6.3) | 269 (6.8) | 602 (6.1) | 1.3 (1.2–1.4) | 1.4 (1.2–1.5) | 1.3 (1.2–1.4) |
Note: Boldface indicates statistical significance at α < .05.
Abbreviations: aPR, adjusted prevalence ratio; CHD, congenital heart defect; CI, confidence interval; PTSD, post-traumatic stress disorder.
CHDs were defined using International Classification of Disease (ICD) 9 and 10 codes; Individuals were considered to have CHDs if they had at least two ICD codes separated by at least 30 days in outpatient encounter data, or at least one ICD code in inpatient encounter data. Individuals were considered to have severe CHDs if they had ICD codes for common truncus, transposition of the great arteries, complete transposition of the great arteries not otherwise specific, double outlet right ventricle or incomplete transposition of the great arteries, corrected transposition of the great arteries, other transposition of the great arteries, tetralogy of Fallot, single ventricle or cor triloculare, endocardial cushion defect, endocardial cushion defect unspecified, atrial septal defect primum, endocardial cushion defect other specified, pulmonary valve atresia or absence, tricuspid atresia, stenosis or absence, hypoplastic left heart syndrome, interrupted aortic arch, total anomalous pulmonary venous return.
For all models comparison is adults without a congenital heart defect diagnosis; models are adjusted for categorical age at the beginning of 2017 (18–29 years, 30–39 years, 40–49 years), sex, and region of residence.
Any anxiety or depressive disorder includes any individual with a diagnosis of an anxiety or depressive disorder in 2017; the codes for post-traumatic stress disorder are also included in the codes used to identify individuals with anxiety disorder.