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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Birth Defects Res. 2021 Dec 21;114(3-4):124–135. doi: 10.1002/bdr2.1971

TABLE 3.

Associations between mental health conditions and characteristics among adults with CHDs, MarketScan® Commercial Database, 2017

Characteristics Any anxiety or depressive disorder Post-traumatic stress disordera Anxiety disorder Depressive disorder
n (%) aPRb (95% CI) n (%) aPRb (95% CI) n (%) aPRb (95% CI) n (%) aPRb (95% CI)
Congenital heart defect severityc
 Severe CHDs 513 (12.9) 1.1 (1.0, 1.2) 34 (0.9) 1.1 (0.7, 1.7) 398 (10.0) 1.0 (0.9, 1.1) 269 (6.8) 1.1 (1.0, 1.3)
 Nonsevere CHDs 1,200 (12.2) Ref 76 (0.8) Ref 973 (9.9) Ref 602 (6.1) Ref
Aged
 18–29 756 (12.4) 1.0 (0.9, 1.1) 44 (0.7) 0.9 (0.6, 1.5) 619 (10.1) 1.1 (0.9, 1.2) 384 (6.3) 1.0 (0.9, 1.2)
 30–39 454 (12.2) 0.9 (0.8, 1.0) 35 (0.9) 1.1 (0.7, 1.7) 368 (9.9) 1.0 (0.8, 1.1) 233 (6.2) 0.9 (0.8, 1.1)
 40–49 503 (12.7) Ref 31 (0.8) Ref 384 (9.7) Ref 254 (6.4) Ref
Sex
 Female 1,067 (15.1) 1.6 (1.5, 1.8) 85 (1.2) 3.3 (2.1, 5.1) 868 (12.3) 1.7 (1.5, 1.9) 555 (7.9) 1.7 (1.5, 2.0)
 Male 646 (9.6) Ref 25 (0.4) Ref 503 (7.4) Ref 316 (4.7) Ref
Region of residence
 Northeast 476 (14.0) 1.2 (1.0, 1.4) 27 (0.8) 0.8 (0.5, 1.4) 376 (11.0) 1.2 (1.0, 1.4) 228 (6.7) 1.0 (0.8, 1.2)
 North Central 391 (12.3) 1.1 (0.9, 1.3) 32 (1.0) 1.0 (0.6, 1.8) 316 (9.9) 1.1 (0.9, 1.3) 211 (6.6) 1.0 (0.8, 1.3)
 South 591 (11.7) 1.0 (0.9, 1.2) 28 (0.6) 0.5 (0.3, 0.9) 471 (9.3) 1.0 (0.8, 1.2) 285 (5.7) 0.8 (0.7, 1.0)
 West 252 (11.8) Ref 23 (1.1) Ref 206 (9.6) Ref 145 (6.8) Ref
Outpatient encounters without mental health psychosocial treatmente
 1–5 encounters 280 (5.4) Ref 12 (0.2) Ref 209 (4.0) Ref 136 (2.6) Ref
 6–10 encounters 360 (10.9) 2.0 (1.7, 2.3) 17 (0.5) 2.1 (1.0, 4.4) 287 (8.7) 2.2 (1.8, 2.6) 155 (4.7) 1.8 (1.4, 2.3)
 11–15 encounters 288 (15.5) 2.9 (2.4, 3.3) 16 (0.9) 3.3 (1.6, 7.1) 228 (12.2) 3.0 (2.5, 3.6) 151 (8.1) 3.1 (2.5, 3.9)
 16–20 encounters 204 (18.7) 3.4 (2.9, 4.1) 11 (1.0) 3.8 (1.7, 8.7) 167 (15.3) 3.8 (3.1, 4.6) 109 (10.0) 3.8 (2.9, 4.8)
 More than 20 encounters 571 (24.9) 4.6 (4.0, 5.3) 53 (2.3) 8.8 (4.7, 16.6) 472 (20.6) 5.2 (4.4, 6.0) 316 (13.8) 5.3 (4.3, 6.4)
Inpatient admissionf
 Yes 381 (21.9) 1.1 (1.0, 1.3) 41 (2.4) 1.9 (1.2, 2.9) 310 (17.8) 1.1 (1.0, 1.3) 223 (12.8) 1.3 (1.1, 1.5)
 No 1,332 (11.0) Ref 69 (0.6) Ref 1,061 (8.8) Ref 648 (5.4) Ref
Surgical cardiovascular encounterf,g
 0 encounters 1,649 (12.2) Ref 107 (0.8) Ref 1,318 (9.7) Ref 838 (6.2) Ref
 ≥1 encounter 64 (23.8) 1.2 (1.0, 1.5) 3 (1.1) 0.8 (0.2, 2.5) 53 (19.7) 1.3 (1.0, 1.6) 33 (12.3) 1.2 (0.9, 1.7)
Catheterization cardiovascular encounterf,g
 0 encounters 1,625 (12.2) Ref 105 (0.8) Ref 1,299 (9.8) Ref 824 (6.2) Ref
 1 encounter 62 (15.9) 0.9 (0.7, 1.2) 3 (0.8) 0.6 (0.2, 1.9) 50 (12.8) 0.9 (0.7, 1.2) 33 (8.5) 0.9 (0.6, 1.3)
 ≥2 encounters 26 (23.2) 1.1 (0.8, 1.5) 2 (1.8) 1.1 (0.3, 4.4) 22 (19.6) 1.1 (0.8, 1.7) 14 (12.5) 1.1 (0.7, 1.8)
Noninvasive cardiovascular encounterf,g
 0 encounters 622 (10.7) Ref 42 (0.7) Ref 496 (8.6) Ref 318 (5.5) Ref
 1 encounter 458 (10.9) 0.9 (0.8, 1.0) 24 (0.6) 0.7 (0.4, 1.2) 348 (8.3) 0.9 (0.8, 1.0) 232 (5.5) 0.9 (0.8, 1.1)
 ≥2 encounters 633 (16.6) 1.0 (0.9, 1.1) 44 (1.2) 0.9 (0.6, 1.4) 527 (13.9) 1.0 (0.9, 1.2) 321 (8.4) 0.9 (0.8, 1.1)

Note: Boldface indicates statistical significance at α < .05.

Abbreviations: aPR, adjusted prevalence ratio; CHD, congenital heart defects; CI, confidence interval.

a

Post-traumatic stress disorder is a subset of anxiety disorders.

b

Adjusted prevalence ratios: Type of congenital heart defect and outpatient encounters without mental health counseling adjusted for categorical age (18–29 years, 30–39 years, 40–49 years), sex, and region; Age adjusted for sex and region; Sex adjusted for categorical age and region, Region adjusted for categorical age and sex; Inpatient admissions and Encounter with cardiovascular procedures adjusted for categorical age, sex, region, and total outpatient encounters without psychosocial treatment.

c

Individuals were considered to have severe CHDs if they had ICD codes for common truncus, transposition of the great arteries, complete transposition of the great arteries not otherwise specific, double outlet right ventricle or incomplete transposition of the great arteries, corrected transposition of the great arteries, other transposition of the great arteries, tetralogy of Fallot, single ventricle or cor triloculare, endocardial cushion defect, endocardial cushion defect unspecified, atrial septal defect primum, endocardial cushion defect other specified, pulmonary valve atresia or absence, tricuspid atresia stenosis or absence, hypoplastic left heart syndrome, interrupted aortic arch, total anomalous pulmonary venous return.

d

Age as of January 1, 2017.

e

Among individuals with at least one outpatient encounter without psychosocial treatment.

f

In 2017.

g

Any inpatient or outpatient encounter that included a cardiovascular procedure code.