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. 2022 Feb 9;13:769. doi: 10.1038/s41467-022-28335-3

Fig. 4. Activation and migration of T cell subsets during acute pharyngitis.

Fig. 4

a CD69+ activation on T cell subsets timepoint 0 h (pre-infection), 24 h post-infection (24 h) and 72 h post-infection (72 h) between pharyngitis positive (n = 19, red) and negative (n = 6, blue) participants. b Unsupervised UMAP analysis of CD69+ expression (black) on unconventional T cell subsets. c Differences in expression of cytotoxic markers (perforin and Granzyme-B) in γδTCR + Vδ2+ T cells, MAIT cells and CD8+ T cells. d Changes in T cell CXCR3+ median fluorescence intensity (MFI) over time. e Unsupervised UMAP analysis of CXCR3+ expression (black) on unconventional T cell subsets. f Spearman’s correlation between CXCR3 expression and IP-10 secretion. Data presented as boxplots show median ± IQR with min–max whiskers. A Friedman’s test was used to compare responses over time in P+ and P− groups, while a Mann–Whitney U-test was performed to compare differences between P+ and P− groups. All tests performed were two-tailed and a p-value <0.05 was considered significant; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.