Table 1.
Baseline characteristics of NSCLC patients.
| Characteristics | Total | IS6110a PCR | P-value | |
|---|---|---|---|---|
| N = 88 | Negative n = 52 | Positive n = 36 | ||
| % (n/N) | % (n/N) | % (n/N) | ||
| Sex | 0.004 | |||
| Male | 30.7 (27/88) | 42.3 (22/52) | 13.9 (5/36) | |
| Female | 69.3 (61/88) | 57.7 (30/52) | 86.1 (31/36) | |
| Age at diagnosis (years) | ||||
| Mean (SD) | 58.48 ± 15.06 | 61.06 ± 13.89 | 54.75 ± 16.07 | 0.050 |
| Age (years) | 0.030 | |||
| < 60 | 50 (44/88) | 40.4 (21/52) | 63.9 (23/36) | |
| ≥ 61 | 50 (44/88) | 59.6 (31/52) | 36.1 (13/36) | |
| Age category | 0.608 | |||
| 20–39 | 10.2 (9/88) | 7.7 (4/52) | 13.9 (5/36) | |
| 40–69 | 64.8 (57/88) | 65.4 (34/52) | 63.9 (23/36) | |
| 70+ | 25 (22/88) | 26.9 (14/52) | 22.2 (8/36) | |
| Body-mass Index (kg/m2) | ||||
| Mean (SD) | 25.57 ± 4.18 | 24.71 ± 4.51 | 25.96 ± 4.01 | 0.977 |
| Median (IQR) | 24.69 (16.2–34) | 24.35 (18.5–32.2) | 25.96 (23.1–28.8) | 0.916 |
| Tobacco exposure | 0.968 | |||
| Absent | 61.4 (54/88) | 61.5 (32/52) | 61.1 (22/36) | |
| Present | 38.6 (34/88) | 38.5 (20/52) | 38.9 (14/36) | |
| Tobacco Index | ||||
| Mean (SD) | 28.27 ± 38.31 | 24.5 ± 31.43 | 27.5 ± 37.4 | 0.726 |
| Median (IQR) | 20 (1–202) | 15 (2–86) | 27.5 (1–54) | 0.506 |
| Wood-smoke exposure | 0.811 | |||
| Absent | 56.8 (50/88) | 55.8 (29/52) | 58.3 (21/36) | |
| Present | 43.2 (38/88) | 44.2 (23/52) | 41.7 (15/36) | |
| Wood-smoke exposure Index | ||||
| Mean (SD) | 102.53 ± 156.39 | 112.16 ± 126.47 | 15.5 ± 10.6 | 0.149 |
| Median (IQR) | 39 (5–816) | 58 (5–300) | 15.5 (8–23) | 0.731 |
| Asbestos exposure | 0.837 | |||
| Absent | 90.9 (80/88) | 90.4 (47/52) | 91.7 (33/36) | |
| Present | 9.1 (8/88) | 9.6 (5/52) | 8.3 (3/36) | |
| Type of disease | 0.692 | |||
| Loco-regional | 40.9 (36/88) | 44.2 (23/52) | 36.1 (13/36) | |
| Oligometastatic | 55.7 (49/88) | 51.9 (27/52) | 61.1 (22/36) | |
| Metastatic | 3.4 (3/88) | 3.8 (2/52) | 2.8 (1/36) | |
| Histology | 0.211 | |||
| Adenocarcinoma | 93.2 (82/88) | 90.4 (47/52) | 97.2 (35/36) | |
| Other | 6.8 (6/88) | 9.6 (5/52) | 2.8 (1/36) | |
| Histology subtype | 0.502 | |||
| Lepidic | 6.8 (6/88) | 3.8 (2/52) | 11.1 (4/36) | |
| Acinar | 30.7 (27/88) | 26.9 (14/52) | 36.1 (13/36) | |
| Papilar | 11.4 (10/88) | 11.5 (6/52) | 11.1 (4/36) | |
| Solid | 26.1 (23/88) | 28.8 (15/52) | 22.2 (8/36) | |
| Not specified | 25 (22/88) | 28.8 (15/52) | 19.4 (7/36) | |
| Clinical stage | 0.420 | |||
| I–II | 5.7 (5/88) | 7.7 (4/52) | 2.8 (1/36) | |
| III | 10.2 (9/88) | 13.5 (7/52) | 5.6 (2/36) | |
| IV | 84.1 (74/88) | 78.8 (41/52) | 91.7 (33/36) | |
| ECOG status | 0.98 | |||
| 0–1 | 85.2 (75/88) | 84.6 (44/52) | 86.1 (31/36) | |
| 2 + | 14.8 (13/88) | 15.4 (8/52) | 13.9 (5/36) | |
| EGFR mutation | ||||
| Wildtype | 16 | 11 | 0.71 | |
| Mutated | 13 | 11 | ||
| Not determined (37) | – | – | ||
Significant values are in bold.
aIS6110: Mycobacterium tuberculosis insertion sequence.
NSCLC Non-small cell lung cancer.