. 2022 Feb 9;12:2227. doi: 10.1038/s41598-022-06343-z

Table 1.

Concordance of HPV type-specific (HPV6, 11, 16, 18, 45) seropositivity between the mothers and their offspring.

Age of the infant	Offspring testing seropositive to the same HPV type as their mothers*
	^aNumber and (percentage) of seropositive offspring / total number of tested offspring at each time point ^bMedian MFI (range)
One month	72/134 (53.7)^a 606 (201–3798)^b	29/53 (54.7) 530 (203–2076)	47/76 (61.8) 538 (201–10,695)	19/47 (40.4) 455 (212–1740)	9/21 (42.9) 341 (209–684)
Two months	42/132 (31.8) 547(202–2023)	17/51 (33.3) 267 (207–1470)	31/86 (36.0) 518 (206–6698)	12/54 (22.2) 273 (207–1094)	4/23 (17.4) 290 (204–446)
Six months	27/140 (19.3) 319 (209–4180)	2/53 (3.8) 287 (238–337)	9/92 (9.8) 269 (207–1577)	8/56 (14.3) 277 (200–401)	0/24
12 months	37/145 (25.5) 850 (201–3167)	5/56 (8.9) 312 (207–585)	10/89 (11.2) 232 (208–255)	13/55 (23.6) 290 (210–652)	0/22
24 months	51/132 (38.6) 877 (207–3110)	4/49 (8.2) 312 (207–585)	13/87(14.9) 420 (201–13,799)	7/47 (14.9) 279(209–1125)	0/22
36 months	43/128 (33.6) 692 (205–2373)	0/47	4/83 (4.8) 2 (203–365)	1/46 (2.2) 1225	0/19

Age of the infant

Offspring testing seropositive to the same HPV type as their mothers*

HPV6
n = 179*

HPV11
n = 70*

HPV16
n = 109*

HPV18
n = 66*

HPV45
n = 31*

^aNumber and (percentage) of seropositive offspring / total number of tested offspring at each time point

^bMedian MFI (range)

One month

72/134 (53.7)^a

606 (201–3798)^b

29/53 (54.7)

530 (203–2076)

47/76 (61.8)

538 (201–10,695)

19/47 (40.4)

455 (212–1740)

9/21 (42.9)

341 (209–684)

Two months

42/132 (31.8)

547(202–2023)

17/51 (33.3)

267 (207–1470)

31/86 (36.0)

518 (206–6698)

12/54 (22.2)

273 (207–1094)

4/23 (17.4)

290 (204–446)

Six months

27/140 (19.3)

319 (209–4180)

2/53 (3.8)

287 (238–337)

9/92 (9.8)

269 (207–1577)

8/56 (14.3)

277 (200–401)

0/24

12 months

37/145 (25.5)

850 (201–3167)

5/56 (8.9)

312 (207–585)

10/89 (11.2)

232 (208–255)

13/55 (23.6)

290 (210–652)

0/22

24 months

51/132 (38.6)

877 (207–3110)

4/49 (8.2)

312 (207–585)

13/87(14.9)

420 (201–13,799)

7/47 (14.9)

279(209–1125)

0/22

36 months

43/128 (33.6)

692 (205–2373)

0/47

4/83 (4.8)

2 (203–365)

1/46 (2.2)

1225

0/19

The seropositivity cut-off in the mother–child pairs ≥ 200 MFI.

*Numbers of mothers seropositive to HPV6 (n = 179), HPV11 (n = 70), HPV16 (n = 109), HPV18 (n = 66) and HPV45 (n = 31).

^aNumbers and (%) of the offspring testing seropositive to the same HPV type as their mothers/the total number of offspring tested at each time point. As an example of HPV6, 179 mothers (out of 327) tested seropositive to HPV6, but only 134 offspring of these mothers were serologically tested at 1-month; 132 at 2-month, 140 at 6-month, 145 at 12-month, 132 at 24-month and 128 at 36-month follow-up visit. The other HPV types follow the same pattern of presentation.

^bMedian MFI values and (range).