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. 2022 Feb 9;12:2145. doi: 10.1038/s41598-022-06104-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Most of the active ingredients present in the mouth rinses did not exhibit inhibitory activity against SARS-CoV-2 3CLpro enzyme. Aloin A, aloin B, chlorhextidine, ecalyptol, hexetidine, menthol, triclosan, methyl salicylate, sodium fluoride and providone iodide were selected for their inhibitory activity against SARS-CoV-2 3CLpro enzyme as described under Materials and Methods. The fluorescence intensity was used to calculate the percent enzymatic activity considering DMSO treated control as 100% activity. Blank values were subtracted from before calculating the percent activity. DMSO (0.1%) with enzyme and 50 µM of substrate served as positive control. Wells with 50 µM of GC-376 served as specificity controls for 3CLpro. Representative of three experiments (n = 3) with triplicate values were presented graphically. P value < 0.001 considered as statistically significant. One-way ANOVA with Bonferroni's Multiple Comparison post-hoc test was used to calculate the statistical significance.