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. 2022 Feb 9;10:11. doi: 10.1038/s41413-021-00182-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Requirement for Ddr2 in Col2a1-positive chondroprogenitor cells. a Gross phenotype of 3 month-old Ddr2^fl/fl and Col2a1-Cre;Ddr2^fl/fl littermates. Col2a1-Cre; Ddr2^fl/fl mice have skeletal dwarfism (n = 20, 10 mice/sex). Scale bar: 2 cm. b Gene expression analysis of Ddr2 from whole 3 month-old tibiae to confirm knockout efficiency (n = 6 mice). c, d Measurements of body length (cm) and weight (g) (n = 20, 10 mice/sex). e 3D micro-computed tomography (microCT) models of the tibial metaphysis and cortical mid-shaft in 3 month-old Ddr2^fl/fl and Col2a1-Cre; Ddr2^fl/fl mice. Scale bar: 100 µm. f–j Quantitative data of trabecular bone volume fraction (Trab. BV/TV), trabecular number (Tb.N), trabecular thickness (Tb.Th), trabecular spacing (Tb.Sp) and bone mineral density (Trab. BMD), (n = 20, 10 mice/sex). k, l Quantification of cortical bone volume fraction (Cort. BV/TV), and bone mineral density (Cort. BMD), (n = 20, 10 mice/sex). m Gene expression analysis of osteogenic and chondrogenic differentiation markers. Statistics: Unpaired t-test *P < 0.05, **P < 0.01; ***P < 0.001; ****P < 0.000 1; ns Not significant. Data were presented as mean ± SD