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. 2022 Feb 9;10:11. doi: 10.1038/s41413-021-00182-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Requirement for Ddr2 in osteoblast differentiation of purified marrow-derived skeletal progenitors. a Flow cytometry analysis and isolation of CD140α/CD51⁺ cells from Ddr2^fl/fl mice. Boxed region (right) shows percentage of BM stem/progenitor cells. b Fold enrichment of Ddr2 and stem cell marker mRNAs in CD140α/CD51⁺ cells. c–e Colony forming unit-fibroblast (CFU-F) and CFU-osteoblasts (CFU-Ob) assays showing Ddr2 deficiency inhibits CFU-Ob. c Representative images of CFU-F and CFU-Ob. d CFU-F. e CFU-Ob. f–i Gene expression analysis of CD140α/CD51⁺ bone marrow cells treated with AdLacz or AdCre and grown in osteogenic medium. Closed bars, AdLacZ (control); open bars, AdCre. Unpaired t-test *P < 0.05, **P < 0.01; ***P < 0.001; ****P < 0.000 1; ns Not significant