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. 2022 Feb 9;13:780. doi: 10.1038/s41467-022-28431-4

Fig. 6. Incorporating unshared chromatin and gene features to integrate spatial transcriptomic and multimodal data.

Fig. 6

a UMAP for iNMF integration of STARmap spatial transcriptomic data and SNARE-seq RNA data only, annotated by jointly examining the SNARE-seq and STARmap labels. b Schematic of how unshared gene and chromatin accessibility data is incorporated into the integration analysis of STARmap and SNARE-seq using UINMF. c The integration is improved significantly by the inclusion of ATAC gene-centric features in the U matrix, annotated by jointly examining the SNARE-seq and STARmap labels. d–e The original cell type labels of STARmap cells (d) and SNARE-seq cells (e) show clear correspondence after UINMF integration.