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. 2022 Jan 27;11:802727. doi: 10.3389/fonc.2021.802727

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Copyright © 2022 Huang, Liu, Wu, Lu, Antony, Zhou, Zhang, Wu, Tan, Fan, You, Jing and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Methylation analysis of SERPINE1. (A) Differential expression of three DNA methyltransferases (DNMT1, DNMT3A and DNMT3B). (B) The methylation site of SERPINE1 DNA sequence association with gene expression was visualized using MEXPRESS. The blue line illustrates the expression of SERPINE1 in the center of the plot. Pearson’s correlation coefficients and p values for methylation sites and query gene expression are shown on the right side. (C) Differently methylated regions associated with SERPINE1 were presented by heatmap using MethSurv.