FIGURE 1.

Inhibition of Sirtuin and HDAC activity in breast cancer cell lines. (A, C) Quantification of the catalytic activity of Sirtuin in ZR-75-1 and MDA-MB-231 cells, respectively, after 48-h treatment, cells were treated with 0–100 µM of AGK2 (black line), EX527 (pink line) or Sirtinol (green line). (B, D) Quantification of the catalytic activity of HDAC in ZR-75-1 and MDA-MB-231 cells, respectively, after 48-h treatment, cells were treated with 0–100 µM of SAHA (black line) or TSA (pink line). Data is presented as the mean ± SEM of four independent experiments.