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. 2021 Nov 19;298(2):101413. doi: 10.1016/j.jbc.2021.101413

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© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Class B1 mutational constraint spectrum.A, observed over expected class B1 missense variants as observed in gnomAD (34). B, allele diversity per residue position in each receptor normalized by receptor length. C, known disease mutations for each receptor from DisGeNET (36). D, number of variants with trait associations as obtained from GeneAtlas (39). ADCYAP1R1, pituitary adenylate cyclase-activating polypeptide type I receptor; CALCR, calcitonin receptor; CALCRL, calcitonin receptor-like receptor; CRHR1, corticotropin-releasing hormone receptor 1; GCGR, glucagon receptor (highlighted); GHRHR, growth hormone releasing hormone receptor; GIPR, glucose-dependent insulinotropic polypeptide receptor; GLP-1R, glucagon-like peptide-1 receptor; GLP-2R, glucagon-like peptide-2 receptor; PTH2R, parathyroid hormone 2 receptor; SCTR, secretin receptor; VIPR1, vasoactive intestinal peptide receptor 1; VIPR2, vasoactive intestinal peptide receptor 2.