Figure 6.

Therapeutic treatment of miR-145-5p agomirs in Cldn8-knockout mice. a. Body weight in Cldn8^−/− mice. b-c, Colon lengths in Cldn8^−/− mice. d-g, miR-145-5p, SOX9 and CLDN8 expressions at mRNA and protein levels. h, MPO activity of the colon. i, Serum FITC-dextran FD40. j-k, Histological scores were assessed by H&E staining of colon tissues (WT+Agomir group, n = 4; Cldn8^−/−+Agomir group, n = 4; Cldn8^−/−+Agomir-control group, n = 4). Scale bars, 50 μm. All Data are shown as means ± SEM in (a), (b), (d), (e), (f), (h), (i) and (j). Student's t-test and one-way ANOVA were used for comparison, respectively. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 as compared with the control.