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. 2022 Jan 27;9:758968. doi: 10.3389/fmolb.2022.758968

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Copyright © 2022 Wang, Zhao, Zhang, Jiang, Ma, Zhang and Dong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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UGT1A3 expression was transcriptionally regulated by USF1. (A) A schematic representation of the location of the motif bound by USF1 at UGT1A3 promoter region. The UGT1A3 promoter region is located at chr2: 233719688–233729126. The USF1 site coordinates is chr2: 233729019–233729025. The coordinate position of TSS is chr2: 233729127. The positions of the UGT1A3 promoter and USF1 site are indicated according to human genome assembly GRCH38/hg38. (B) The relationship of USF1 and UGT1A3 was studied by Dual-luciferase reporter assay; (C) Cell viability was detected by CCK-8 assay in H1299 cell; (D) Transfection efficiency was determined by WB in H1299 cell; (E,F) Cell migration was detected by wound healing assay in H1299 cell. (si-USF1+UGT1A3 group stood for cells transfected with si-USF1 and pCDNA3.1-UGT1A3; *p < .05 means statistically significant difference when compared with NC group).