TABLE 2.

The biological functions and molecular mechanisms of miR-30d-5p.

Cancer type	Property	Functions	Genes/proteins/pathways	Refs
Lung cancer	Suppressor	Cell proliferation and motility inhibitor	Targeting CCNE2	Chen et al. (2015)
	Suppressor	Cell proliferation, migration, and invasion inhibitor	Targeted by POU3F3	Zeng et al. (2020)
	Suppressor	Cell proliferation, migration, and invasion inhibitor	Targeting DBF4	Qi et al. (2021)
	Suppressor	Cell proliferation, invasion and stemness inhibitor	circCD151/miR-30d-5p/GLI2 axis	Zhao et al. (2021)
	Suppressor	Malignant progression inhibitor and immune escape	LncRNA SOX2OT/miR-30d-5p/PDK1 driving PD-L1 through the mTOR signaling pathway	Chen et al. (2021)
Gallbladder carcinoma	Suppressor	Cell apoptosis promoter, and migration inhibitor	Targeting LDHA	He et al. (2018)
Rectal cancer	Suppressor	Organ-specificity of metastasis inhibitor	—	Bjørnetrø et al. (2019)
Colon cancer	Suppressor	TNM	—	Jacob et al. (2017)
	Suppressor	Cell proliferation, metastasis and lymph node inhibitor, tumor stage	LncRNA PVT1/miR-30d-5p/RUNX2 axis	Yu et al. (2018)
Prostate cancer	Suppressor	Cell proliferation, and migration inhibitor	Targeting NT5E	Song et al. (2018)
	Suppressor	Cell proliferation inhibitor	AR (Androgen receptor) regulating	Kumar et al. (2016)
Esophageal squamous cell carcinoma	Suppressor	Cell proliferation, migration, invasion inhibitor, and EMT inhibitor	LOC440173/miR-30d-5p/HDAC9 axis	Wang et al. (2020)
	Suppressor	Cell proliferation and invasion inhibitor, EMT inhibitor	Sponged by DDX11-AS1, regulating SNAI1/ZEB2 and Wnt/β-catenin pathway	Guo et al. (2021)
Renal cell carcinoma	Suppressor	Cell proliferation inhibitor, and autophagy promotor	Targeting ATG5	Liang et al. (2021)
Pancreatic cancer	Suppressor	Metastasis	miR-30d-5p/GJA1 CTNNA1, CTNNB1, CTNND1	Zheng et al. (2021)
Osteosarcoma	Oncogene	Cell migration, invasion, proliferation inhibitor, apoptosis promotor, and EMT	Regulating SOCS3/JAK2/STAT3 pathway	Hu Y. et al. (2021)
Thyroid cancer	Suppressor	Tumorigenesis	LINC00284/miR-30d-5p/ADAM12 regulating Notch signaling pathway	Hu C. et al. (2021)
Hepatocellular carcinoma	Suppressor	Cell migration inhibitor	—	Yu et al. (2019)
	Suppressor	Autophagy	Targeting GLDC	Zhuang et al. (2019)