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. 2022 Jan 27;9:740712. doi: 10.3389/fbioe.2021.740712

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Copyright © 2022 Nowwarote, Petit, Ferre, Dingli, Laigle, Loew, Osathanon and Fournier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary. Extracellular matrix (ECM) from human dental pulp stem cells was produced by two conditions (N-ECM—normal medium supplement with ascorbic acid, and OM-ECM—osteogenic induction medium) for 21 days. ECM in normal and mineralized conditions enhance mineralization of gingival fibroblasts after reseeding on ECM. Proteomic analysis of ECM was defined by matrisome database. Normal conditions ECM (N-ECM) shows enrichment of collagens and elastic fibers formation. On the other hand, mineralized conditions ECM (OM-ECM) shows enrichment of matrisome-affiliated proteins.