Table 2.
[18F]DPA-714 binding in FLAIR hyperintense regions.
| PET characteristic | C+ (n = 15) | paired t-test |
C- (n = 15) | paired t-test |
HC (n = 13) | paired t-test |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| t | puncorrected | t | puncorrected | t | puncorrected | |||||||
| VT, mean (SD) | ||||||||||||
| NAWM | 1.20 | (0.47) | – | – | 1.14 | (0.30) | – | – | 1.10 | (0.42) | – | – |
| total WML | 1.17 | (0.53) | 1.87 | 1.11 | (0.34) | 1.54 | 0.145 | 1.09 | (0.45) | 0.87 | 0.402 | |
| periventricular WML | 1.14 | (0.49) | 2.67 | 0.018 | 1.07 | (0.34) | 2.48 | 0.026 | 1.08 | (0.46) | 1.07 | 0.306 |
| juxtacortical WML | 1.91 | (1.12) | 5.04 | 0.002* | 1.33 | (0.36) | 3.90 | 0.008* | 1.42 | (0.34) | 2.58 | 0.049 |
| deep white matter WML | 1.23 | (0.53) | 0.75 | 0.467 | 1.16 | (0.33) | 1.54 | 0.146 | 1.13 | (0.47) | 0.32 | 0.756 |
| PVC VT, mean (SD) | ||||||||||||
| NAWM | 1.12 | (0.42) | – | – | 1.09 | (0.28) | – | – | 1.05 | (0.39) | – | – |
| total WML | 1.12 | (0.42) | 1.75 | 0.360 | 1.08 | (0.32) | 0.97 | 0.345 | 1.05 | (0.39) | 0.32 | 0.755 |
| periventricular WML | 1.09 | (0.43) | 2.62 | 0.020 | 1.07 | (0.32) | 1.61 | 0.129 | 1.04 | (0.39) | 0.39 | 0.706 |
| juxtacortical WML | 1.62 | (0.99) | 4.29 | 0.005* | 1.20 | (0.32) | 2.86 | 0.029 | 1.28 | (0.35) | 1.86 | 0.122 |
| deep white matter WML | 1.12 | (0.43) | 0.23 | 0.821 | 1.07 | (0.29) | 0.52 | 0.613 | 1.06 | (0.40) | 0.08 | 0.932 |
Only regions with a minimum of two voxels were evaluated. * Surviving Bonferonni correction for comparing four outcomes (p < 0.0125).
Abbreviations: C- = chemotherapy-naïve breast cancer patients, C+ = breast cancer patients treated with chemotherapy, FLAIR = fluid attenuated inversion recovery sequence, HC = healthy controls, PET = positron emission tomography, PVC = region-based voxel-wise partial volume corrected, SD = standard deviation, VT = total volume of distribution, WML = white matter lesions, observed as hyperintense regions on FLAIR magnetic resonance imaging.