Intervention(s) and comparator(s)	Participants included in analysis [N]	Participants discontinuing trial due to an adverse event [N]	Participants discontinuing trial due to an adverse event [%]
Umpierrez 2004a	I: s.c. insulin lispro	20	0	0
	C: i.v. regular insulin	20	0	0
Umpierrez 2004b	I1: s.c. insulin aspart, every hour	15	0	0
	I2: s.c. insulin aspart, every 2 h	15	0	0
	C: i.v. regular insulin	15	0	0
Della Manna 2005	I: s.c. insulin lispro	25	0	0
	C: i.v. regular insulin	21	‐	‐
Ersöz 2006	I: s.c. insulin lispro	10	0	0
	C: i.v. regular insulin	10	0	0
Karoli 2011	I: s.c. insulin lispro	25	0	0
	C: i.v. regular insulin	25	0	0
‐ denotes not reported C: comparator; I: intervention; i.v.: intravenous; s.c.: subcutaneous