Figure 14.

Tissue engineering applications of PA, RADA, and Q11 SAPs. (A) Encapsulation of myogenic precursor cells in aligned PA scaffolds yielded higher cell viability at all timepoints compared to unencapsulated cells, especially in scaffolds with mid-range (G’ ~9 kPa) and high (G’ ~15 kPa) moduli. C₂C₁₂ cells (green) in the PA scaffold (red) grew along the axis of alignment, with the white arrow heads indicating dead cells. Adapted with permission from Sleep et al. [25], Copyright (2017) National Academy of Sciences U.S.A. (B) Application of commercially available PuraStat RADA hydrogels to the surface of cardiac tissue decreased probability of heart failure in mice. Adapted with permission from Giritharan et al. [360], Copyright (2018) BioMed Central Ltd. (C) Mice injected subcutaneously near the shoulder blades with coassemblies of OVA-Q11 and NANP3-Q11 elicited heightened immune responses compared to those receiving separate injections of the two peptides. The Y axis represents the degree of antibody production responses. Adapted with permission from Rudra et al. [315], Copyright (2012) Elsevier.