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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Acta Biomater. 2021 Oct 25;140:43–75. doi: 10.1016/j.actbio.2021.10.030

Figure 7.

Figure 7.

pH-dependent assembly of glutamic acid-containing E3 and lysine-containing K3 peptides. CD spectra of the E3, K3 and their equimolar mixture in 10 mM PBS at (A) pH 7 and (B) pH 5. Both E3 and K3 are random coils while their heterodimeric assembly is helical at pH 7. At pH 5, the heterodimer partially unfolds into E3 trimers and random coil K3 unimers. (C) Schematic of E3 (blue) and K3 (green) peptides self- assembly at pH 7 and pH 5. Adapted with permission from Apostolovic and Klok [124], Copyright (2008) American Chemical Society.