FIGURE 2.

Summary of phenotypical alteration of DGKε-KO mice during the course of HFD feeding regimen. Pathophysiological alterations in body weight, adiposity in epididymal white adipose tissue (insets), and glucose tolerance are shown during the course of HFD feeding (Nakano et al., 2018, 2020). Note that in DGKε-KO mice under long-term HFD feeding beige adipogenesis as shown by multilocular cells is induced, which coincides with improved glucose tolerance. HFD, high fat diet; εKO, DGKε-KO mice; WT, wild-type mice.