Table 1.

Trial population

Inclusion criteria
	Patients presenting with acute ischemic stroke eligible using standard criteria to receive IV thrombolysis within 4.5 hours of stroke onset
	Age ≥18 years
	Intra-arterial clot retrieval treatment can commence (groin puncture) within 6 hours of stroke onset.
	Arterial occlusion on CTA or MRA of the ICA, M1, M2 or basilar artery
Exclusion criteria
	Intracranial hemorrhage (ICH) identified by CT or MRI
	Rapidly improving symptoms at the discretion of the investigator
	Pre-stroke mRS score of ≥4 (indicating previous disability)
	Hypodensity in >1/3 MCA territory on non-contrast CT
	Contra indication to imaging with contrast agents
	Any terminal illness such that patient would not be expected to survive more than 1 year
	Any condition that, in the judgment of the investigator could impose hazards to the patient if study therapy is initiated or affect the participation of the patient in the study.
	Pregnant women

IV, intravenous; CTA, computed tomography angiography; MRA, magnetic resonance angiography; ICA, internal carotid artery; CT, computed tomography; MRI, magnetic resonance imaging; mRS, modified Rankin Scale; MCA, middle cerebral artery.